5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole → 4-(tert-Butoxycarbonyl)-2-[[2-(4-chlorophenyl)-4-methylthiazol-5-yl]methoxymethyl]morpholine

Participants

Role	Name	HCID	Charge
Reactant	5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole	HCID 2763694	—
Reactant	tert-Butyl 2-(hydroxymethyl)morpholine-4-carboxylate	HCID 5201202	—
Product	4-(tert-Butoxycarbonyl)-2-[[2-(4-chlorophenyl)-4-methylthiazol-5-yl]methoxymethyl]morpholine	HCID 58992586	69%

Reaction Steps

Using 4-(tert-butoxycarbonyl)morpholin-2-ylmethanol (217 mg, 1.00 mmol) and 5-chloromethyl-2-(4-chlorophenyl)-4-methylthiazole (258 mg, 1.00 mmol), the same procedure was followed as in Step 5a of Example 5 to give 303 mg (69%) of the desired compound as a yellow oil.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07902367B2
Source dataset	uspto-grants-2011_03
ORD ID	ord-a8c8ab09ba804ad1883e637058be9dde
Source note	uspto-grants-2011_03