Aniline → 2-Anilino-4-methoxybenzoic acid

Reaction equation

F[C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[NH:5][C:6]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:7]=1[C:8]([OH:10])=[O:9].NC1C=CC=CC=1>>[NH:5]([C:6]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:7]=1[C:8]([OH:10])=[O:9])[C:4]1[CH:3]=[CH:2][CH:19]=[CH:18][CH:17]=1

Participants

Reactant 2

HCID 6115Aniline

HCID 666462372-(3-Fluoro-anilino)-4-methoxybenzoic acid

Product 1

HCID 126480272-Anilino-4-methoxybenzoic acid

Procedure

Following the procedure for 2-(3-fluoro-anilino)-4-methoxybenzoic acid, using aniline in place of 3-fluoroaniline, 2-anilino-4-methoxybenzoic acid was obtained.

Sources & evidence

ORD record: ord-0517a31c5ba442939a34cdb29b7c7b03
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07906521B2

Reaction notes

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