Tert-butyl 2-diazoacetate → HCID 178496244, compound

HRID 604439

Reaction equation

HRID 604439 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][CH2:7][O:8][CH2:9][C:10]#[CH:11].[C:12]([O:16][C:17](=[O:21])[CH:18]=[N+:19]=[N-:20])([CH3:15])([CH3:14])[CH3:13]>>[C:12]([O:16][C:17]([C:18]1[NH:19][N:20]=[C:10]([CH2:9][O:8][CH2:7][CH2:6][O:5][CH2:4][CH2:3][O:2][CH3:1])[CH:11]=1)=[O:21])([CH3:15])([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 5097903Tert-butyl 2-diazoacetateHCID 183816833-[2-(2-Methoxyethoxy)ethoxy]prop-1-yne

Product 1

HCID 178496244HCID 178496244, compound

Conditions

Temperature
70 °C

Procedure

To a solution containing approx. 2.5 g 3-[2-(2-Methoxy-ethoxy)-ethoxy]-propyne, 2.8 g Diazo-acetic acid tert-butyl ester were added and the mixture was heated to 70° C. for 5 days. Then the solution was concentrated under reduced pressure and directly purified by chromatography on silica eluting with a n-heptane/ethyl acetate gradient. Yield: 1.7 g.

Workup

  1. additionwere added
  2. concentrationThen the solution was concentrated under reduced pressure
  3. customdirectly purified by chromatography on silica eluting with a n-heptane/ethyl acetate gradient

Sources & evidence

ORD record
ord-2e5006ab6c204dcf9cdbd0ebe55193eb
Source dataset
uspto-grants-2011_03
Patent number
US07910606B2

Linked notes

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