2-Amino-5-fluoropyridine → 4-Fluoro-N-(5-fluoro-pyridin-2-yl)-3-nitro-benzamide

HRID 605234

Reaction equation

HRID 605234 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[F:14][C:15]1[CH:16]=[CH:17][C:18]([NH2:21])=[N:19][CH:20]=1>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:21][C:18]2[CH:17]=[CH:16][C:15]([F:14])=[CH:20][N:19]=2)=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12]

Participants

3

Reactant 2

HCID 27377012-Amino-5-fluoropyridineHCID 27833474-Fluoro-3-nitrobenzoyl chloride

Product 1

HCID 632362064-Fluoro-N-(5-fluoro-pyridin-2-yl)-3-nitro-benzamideYield 98%

Procedure

The product from Example 172a was reacted with 5-Fluoro-pyridin-2-ylamine (165 mg, 1.474 mmol) according to the procedure from Example 172a to provide the title compound (404 mg, 98%).

Sources & evidence

ORD record
ord-4d6b36906a434091b7586babc95d131b
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Linked notes

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