HCID 2727950, compound → (5-Amino-2-morpholinophenyl)methanol
Reaction equation
[N:1]1([C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][C:8]=2[CH2:16][OH:17])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1>C(O)C>[NH2:13][C:10]1[CH:11]=[CH:12][C:7]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[C:8]([CH2:16][OH:17])[CH:9]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of (2-morpholin-4-yl-5-nitro-phenyl)-methanol (870 mg) in ethanol (40 mL) palladium hydroxide (87 mg) is added and the mixture is stirred in a Parr-apparatus under hydrogen pressure (10 bars) for 4 hours. The reaction mixture is filtrated over Celite 521, washed with ethanol and concentrated in vacuo to give the title compound (640 mg, 83%).
Workup
- filtrationThe reaction mixture is filtrated over Celite 521
- washwashed with ethanol
- concentrationconcentrated in vacuo
Sources & evidence
- ORD record
- ord-802a9c54d85f42a69038056f4cfe0497
- Source dataset
- uspto-grants-2011_03
- Patent number
- US07915256B2
Reaction notes
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