4,4,5,5-Tetramethyl-2-(thiophen-3-yl)-1,3,2-dioxaborolane → (4-Morpholin-4-ylphenyl)-(5-thiophen-3-yl-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)amine

HRID 605927Notes

Reaction equation

HRID 605927 reaction equation
Br[C:2]1[N:7]2[N:8]=[CH:9][N:10]=[C:6]2[C:5]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)=[CH:14][CH:13]=2)=[N:4][CH:3]=1.CC1(C)C(C)(C)OB([C:32]2[CH:36]=[CH:35][S:34][CH:33]=2)O1>>[N:18]1([C:15]2[CH:16]=[CH:17][C:12]([NH:11][C:5]3[C:6]4[N:7]([N:8]=[CH:9][N:10]=4)[C:2]([C:32]4[CH:36]=[CH:35][S:34][CH:33]=4)=[CH:3][N:4]=3)=[CH:13][CH:14]=2)[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 27605974,4,5,5-Tetramethyl-2-(thiophen-3-yl)-1,3,2-dioxaborolaneHCID 57589931(5-Bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-(4-morpholin-4-ylphenyl)amine

Product 1

HCID 24888777(4-Morpholin-4-ylphenyl)-(5-thiophen-3-yl-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)amine

Procedure

This compound may be prepared using methods as described for Compound 120, using (5-bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-(4-morpholin-4-ylphenyl)amine and 4,4,5,5-tetramethyl-2-thiophen-3-yl-[1,3,2]dioxaborolane in step 4. LCMS: Rt 1.19 min (95%), m/z (ESI) 379 (M+H)+.

Workup

  1. customThis compound may be prepared

Sources & evidence

ORD record
ord-4923b97bbeaf4d0283e63fe4266baee9
Source dataset
uspto-grants-2011_03
Patent number
US07915256B2

Reaction notes

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