Sulfuric Acid → HCID 14958697, compound
Reaction equation
[C:1]([C:3]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[CH:9]=1)=[CH:4][C:5]([O-:7])=[O:6])#N.[K+].S(=O)(=O)(O)[OH:17]>C(O)=O>[CH3:14][C:10]1[CH:9]=[C:8]([C:3]2[C:1](=[O:17])[O:6][C:5](=[O:7])[CH:4]=2)[CH:13]=[CH:12][CH:11]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A suspension of potassium 3-cyano-3-(3-methylphenyl)-acrylate (0.69 g, 3 mmol), in 88% formic acid (14 ml) containing concentrated sulphuric acid (2 ml) was stirred at reflux and monitored by LC-MS until the starting material was consumed. The reaction mixture was cooled to room temperature and poured into ice/water. The resulting precipitate was recovered by filtration, washed with water (15 ml), heptane (15 ml) and air dried.
Workup
- temperatureat reflux
- customwas consumed
- additionpoured into ice/water
- filtrationThe resulting precipitate was recovered by filtration
- washwashed with water (15 ml), heptane (15 ml) and air
- customdried
Sources & evidence
- ORD record
- ord-846e971299b046ee8ef27905903a57d5
- Source dataset
- uspto-grants-2011_03
- Patent number
- US07915304B2
Reaction notes
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