Sulfuric Acid → 2-Amino-5-nitrobenzamide

HRID 606489

Reaction equation

HRID 606489 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[C:4]#[N:5].S(=O)(=O)(O)[OH:14]>>[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[C:4]([NH2:5])=[O:14]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 285322-Amino-5-nitrobenzonitrile

Product 1

HCID 976652-Amino-5-nitrobenzamide

Conditions

Temperature
130 °C

Procedure

A mixture of 2-amino-5-nitrobenzonitrile (25.4 g) and sulfuric acid (70 mL) was stirred at 130° C. for 40 min. The reaction mixture was added slowly to ice water, and the precipitate was collected by filtration, washed with water, ethanol and diethyl ether to give 2-amino-5-nitrobenzamide (24.6 g).

Workup

  1. filtrationthe precipitate was collected by filtration
  2. washwashed with water, ethanol and diethyl ether

Sources & evidence

ORD record
ord-81a291086d23419792bc4437853ea22c
Source dataset
uspto-grants-2011_03
Patent number
US07915267B2

Linked notes

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