8-Quinolinecarboxylic acid → N-((1-(5-(3-Fluorophenyl)-2-methylthiazole-4-carbonyl)-5-methoxypiperidin-2-yl)methyl)quinoline-8-carboxamide

HRID 60828

Reaction equation

HRID 60828 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][CH:6]([O:9][CH3:10])[CH2:5][N:4]1[C:11]([C:13]1[N:14]=[C:15]([CH3:25])[S:16][C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=1)=[O:12].[N:26]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][C:34]=2[C:36](O)=[O:37])[CH:29]=[CH:28][CH:27]=1>>[F:24][C:20]1[CH:19]=[C:18]([C:17]2[S:16][C:15]([CH3:25])=[N:14][C:13]=2[C:11]([N:4]2[CH2:5][CH:6]([O:9][CH3:10])[CH2:7][CH2:8][CH:3]2[CH2:2][NH:1][C:36]([C:34]2[CH:33]=[CH:32][CH:31]=[C:30]3[C:35]=2[N:26]=[CH:27][CH:28]=[CH:29]3)=[O:37])=[O:12])[CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 665828-Quinolinecarboxylic acidHCID 89739331(2-(Aminomethyl)-5-methoxypiperidin-1-yl)(5-(3-fluorophenyl)-2-methylthiazol-4-yl)methanone

Product 1

HCID 71715334N-((1-(5-(3-Fluorophenyl)-2-methylthiazole-4-carbonyl)-5-methoxypiperidin-2-yl)methyl)quinoline-8-carboxamide

Procedure

The title compound was prepared according to general procedure A using (2-(aminomethyl)-5-methoxypiperidin-1-yl)(5-(3-fluorophenyl)-2-methylthiazol-4-yl)methanone and quinoline-8-carboxylic acid. (ESI) 519 (M+H).

Sources & evidence

ORD record
ord-94fb3b1ecc2e44388d79f38f8bffef69
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Linked notes

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