2,5-Dichloropyrimidine → HCID 131737139, compound

HRID 60849

Reaction equation

HRID 60849 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1.[NH2:9][CH2:10][C@H:11]1[C@@H:16]([O:17][CH3:18])[CH2:15][CH2:14][CH2:13][N:12]1[C:19]([C:21]1[N:22]=[C:23]([CH3:33])[S:24][C:25]=1[C:26]1[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=1)=[O:20]>>[Cl:8][C:5]1[CH:4]=[N:3][C:2]([NH:9][CH2:10][C@H:11]2[C@@H:16]([O:17][CH3:18])[CH2:15][CH2:14][CH2:13][N:12]2[C:19]([C:21]2[N:22]=[C:23]([CH3:33])[S:24][C:25]=2[C:26]2[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=2)=[O:20])=[N:7][CH:6]=1

Participants

3

Reactant 2

HCID 5906412,5-DichloropyrimidineHCID 131737138rac-cis-(2-(Aminomethyl)-3-methoxypiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone

Product 1

HCID 131737139HCID 131737139, compound

Procedure

The title compound was prepared following the same general protocol as described for Example 16 using 2,5-dichloropyrimidine and rac-cis-(2-(aminomethyl)-3-methoxypiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone. MS (ESI) 476.0 (M+H).

Sources & evidence

ORD record
ord-bd2361047fdf465ba4eb449179b42927
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Linked notes

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