2-Phenoxybenzoic acid → rac-cis-(3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl) (2-phenoxyphenyl)methanone

HRID 60876

Reaction equation

HRID 60876 reaction equation
[O:1]([C:8]1[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10]([OH:12])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:17][C@H:18]1[CH2:23][CH2:22][CH2:21][NH:20][C@H:19]1[CH2:24][NH:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][N:27]=1>>[CH3:17][C@H:18]1[CH2:23][CH2:22][CH2:21][N:20]([C:10]([C:9]2[CH:13]=[CH:14][CH:15]=[CH:16][C:8]=2[O:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[O:12])[C@H:19]1[CH2:24][NH:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:33])[F:34])=[CH:28][N:27]=1

Participants

3

Reactant 2

HCID 752372-Phenoxybenzoic acidHCID 131737152rac-cis-N-((3-Methylpiperidin-2-yl)methyl)-5-(trifluoromethyl)pyridin-2-amine

Product 1

HCID 131737156rac-cis-(3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl) (2-phenoxyphenyl)methanone

Procedure

The title compound was synthesized following the same general protocol as described in Example 11 using 2-phenoxybenzoic acid and rac-cis-N-((3-methylpiperidin-2-yl)methyl)-5-(trifluoromethyl)pyridin-2-amine. ESI-MS (m/z): 470, [M+1]+.

Sources & evidence

ORD record
ord-218977b2224e44238add87319fa1d837
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Linked notes

Loading…