5-Bromothiazole → 5-Methyl-2-(thiazol-5-yl)benzoic acid

HRID 60931

Reaction equation

[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:11]2[CH:16]=[N:15][CH:14]=CN=2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].BrC1[S:22]C=NC=1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:11]2[S:22][CH:14]=[N:15][CH:16]=2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

Participants

Reactant 2

HCID 5460595-Bromothiazole

HCID 811116085-Methyl-2-(2-pyrazinyl)benzoic acid

Product 1

HCID 1177279765-Methyl-2-(thiazol-5-yl)benzoic acid

Procedure

The title compound was prepared following the same general protocol as described for 5-methyl-2-(pyrazin-2-yl)benzoic acid in Example A19, starting from 5-bromothiazole. ESI-MS (m/z): 220 [M+1]+.

Sources & evidence

ORD record: ord-dc67d6173c0e45f790d875ea8fe517ff
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09440982B2

Linked notes

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