HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dichloropyrimidine → Methyl 2-(2-chloropyrimidin-4-yl)-5-methylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dichloropyrimidine | HCID 77531 | — |
| Reactant | Methyl 5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate | HCID 46856403 | — |
| Reactant | Methyl 5-methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoate | HCID 117727848 | — |
| Product | Methyl 2-(2-chloropyrimidin-4-yl)-5-methylbenzoate | HCID 117727617 | — |
Reaction Steps
The title compound was synthesized following the same general protocol as described for methyl 5-methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoate in Example A1, using methyl 5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate and 2,4-dichloropyrimidine. ESI-MS (m/z): 263 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440982B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-5d81e4ba5f6343f09f530925509d1f00 |
| Source note | uspto-grants-2016_09 |