1-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → 5-Methyl-2-(1-methyl-1H-pyrazol-5-yl)benzoic acid

Reaction equation

[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:11]2[CH:12]=NN(C)C=2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[CH3:17][N:18]1C(B2OC(C)(C)C(C)(C)O2)=C[CH:20]=[N:19]1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:11]2[N:19]([CH3:20])[N:18]=[CH:17][CH:12]=2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

Participants

Reactant 2

HCID 49129081-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

HCID 811115005-Methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoic acid

Product 1

HCID 811112815-Methyl-2-(1-methyl-1H-pyrazol-5-yl)benzoic acid

Procedure

The title compound was synthesized following the same general protocol as described for 5-methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoic acid in Example A1, using 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. ESI-MS (m/z): 217 [M+1]+.

Sources & evidence

ORD record: ord-abec4444dbb34b1f9665e18a6537c517
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09440982B2

Reaction notes

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