N-Piperidinoethanol → SB 203186

Reaction equation

[N:1]1([CH2:7][CH2:8][OH:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12]([C:19](Cl)=[O:20])=[CH:11]1>>[NH:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12]([C:19]([O:9][CH2:8][CH2:7][N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[O:20])=[CH:11]1

Participants

Reactant 2

HCID 18232N-Piperidinoethanol

HCID 123802781H-Indole-3-carbonyl chloride

Product 1

HCID 3272300SB 203186

Procedure

1-Piperidineethanol was reacted with 1H-indole-3-carboxylic acid chloride using the method described in Example 1 a to afford 2-(1-piperidyl)ethyl 1H-indole-3-carboxylate.

Sources & evidence

ORD record: ord-2443697cff5a44b3ad3dec91489c357e
Source dataset: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05998409

Reaction notes

Loading…