(1-Butylpiperidin-4-yl)methanol → (1-n Butyl-4-piperidyl)methyl 5-fluoroindole-3-carboxylate

HRID 609602

Reaction equation

HRID 609602 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:11](Cl)=[O:12].[CH2:14]([N:18]1[CH2:23][CH2:22][CH:21]([CH2:24][OH:25])[CH2:20][CH2:19]1)[CH2:15][CH2:16][CH3:17]>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:11]([O:25][CH2:24][CH:21]1[CH2:22][CH2:23][N:18]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:19][CH2:20]1)=[O:12]

Participants

3

Reactant 2

HCID 10241250(1-Butylpiperidin-4-yl)methanolHCID 543282495-Fluoroindole-3-carboxylic acid chloride

Product 1

HCID 53920547(1-n Butyl-4-piperidyl)methyl 5-fluoroindole-3-carboxylateYield 30%

Procedure

5-Fluoroindole-3-carboxylic acid chloride was reacted with (1-n butyl-4-piperidyl)methanol (D6) using the method of Example 1a to afford (1-n butyl -4-piperidyl)methyl 5-fluoroindole-3-carboxylate as an orange oil (30%), following flash chromatography on silica gel eluting with 10% ethanol/chloroform.

Sources & evidence

ORD record
ord-6bdb956acca849a29fee6c8b703316c2
Source dataset
uspto-grants-1999_12
Patent number
US05998409

Linked notes

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