Bromine → 2-Bromo-1-(2,5-difluorophenyl)propan-1-one
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9](=[O:12])[CH2:10][CH3:11].[Br:13]Br>C(OCC)C>[Br:13][CH:10]([CH3:11])[C:9]([C:3]1[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=1[F:1])=[O:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 2',5'-difluoropropiophenone (2.12 g) in diethyl ether (20 ml) under ice-cooling was added bromine dropwise, and the mixture was stirred at room temperature overnight. To this reaction mixture was added ice and the diethyl ether layer was separated, followed by washing with water and saturated aqueous solution of sodium hydrogen carbonate in that order and dried over anhydrous magnesium sulfate (MgSO4). The either layer was concentrated under reduced pressure to provide the title compound.
Workup
- additionTo this reaction mixture was added ice
- customthe diethyl ether layer was separated
- washby washing with water and saturated aqueous solution of sodium hydrogen carbonate in that order
- dry with materialdried over anhydrous magnesium sulfate (MgSO4)
- concentrationThe either layer was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-3a2af378552a4d619a718a80242d055f
- Source dataset
- uspto-grants-1999_12
- Patent number
- US05998459
Reaction notes
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