Propionyl chloride → 1-Ethyl-5-propionyl-2,3-dihydro-indol-2-one

HRID 610081Notes

Reaction equation

[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][C:4]1=[O:12])[CH3:2].[C:13](Cl)(=[O:16])[CH2:14][CH3:15]>>[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][C:8]([C:13](=[O:16])[CH2:14][CH3:15])=[CH:9][CH:10]=2)[CH2:5][C:4]1=[O:12])[CH3:2]

Participants

Reactant 2

HCID 62324Propionyl chloride

HCID 66135N-Ethyloxindole

Product 1

HCID 196009721-Ethyl-5-propionyl-2,3-dihydro-indol-2-one

Procedure

Prepared from readily available starting materials (N-ethyloxindole and propionyl chloride) in a manner analogous to that set forth in Preparation 18.

Workup

customPrepared
customforth in Preparation 18

Sources & evidence

ORD record: ord-f505cca5258b4ba7ab54401575c335a6
Source dataset: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05998463

Reaction notes

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