Methanol → 3,5,6-Trifluoro-4-methylpyridin-2-amine
Reaction equation
CO.C([NH:10][C:11]1[C:16]([F:17])=[C:15]([CH3:18])[C:14]([F:19])=[C:13]([F:20])[N:12]=1)C1C=CC=CC=1>[Pd].C(O)(=O)C>[NH2:10][C:11]1[C:16]([F:17])=[C:15]([CH3:18])[C:14]([F:19])=[C:13]([F:20])[N:12]=1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
To 4 ml of methanol were added all amount of the crude 2-benzylamino-3,5,6-trifluoro-4-methylpyridine as described above together with 0.18 g of 10% palladium on carbon and 2 ml of acetic acid, and the mixture was hydrogenated at 50° C. for one day. The catalyst was separated by filtration, and the solvent and the like were distilled off under reduced pressure to obtain 1.35 g of the title compound as a colorless solid.
Workup
- customThe catalyst was separated by filtration
- distillationthe solvent and the like were distilled off under reduced pressure
Sources & evidence
- ORD record
- ord-33fb23e7438f4ce4aa9d4e4ca323c6c0
- Source dataset
- uspto-grants-1999_12
- Patent number
- US05998436
Reaction notes
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