Methanol → 3,5-Difluoro-6-methoxypyridin-2-amine
Reaction equation
[CH3:1][OH:2].[NH2:3][C:4]1[C:9]([F:10])=[CH:8][C:7]([F:11])=[C:6](F)[N:5]=1.C[O-].[Na+].CO>C(Cl)(Cl)Cl>[NH2:3][C:4]1[C:9]([F:10])=[CH:8][C:7]([F:11])=[C:6]([O:2][CH3:1])[N:5]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 70 °C
Procedure
To 1 ml of methanol were added 500 mg of 2-amino-3,5,6-trifluoropyridine together with 800 mg of 28% sodium methoxide/methanol solution, and the mixture was stirred at 70° C. for 3 and half hours, and allowed to cool. After adding 25 ml of chloroform, the mixture was washed with 5 ml of distilled water. The chloroform layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain the title product.
Workup
- temperatureto cool
- washthe mixture was washed with 5 ml of distilled water
- dry with materialThe chloroform layer was dried over anhydrous magnesium sulfate
- concentrationconcentrated under reduced pressure
Sources & evidence
- ORD record
- ord-b4c8d8b16e8b47df8803f0b1256fe96c
- Source dataset
- uspto-grants-1999_12
- Patent number
- US05998436
Reaction notes
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