2-Furancarbonyl chloride → 5-(N-[2-furoyl]amino)-3-(piperidin-4-yl)pyrrolo[3,2-b]pyridine

HRID 610555

Reaction equation

HRID 610555 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1.[O:24]1[CH:28]=[CH:27][CH:26]=[C:25]1[C:29](Cl)=[O:30]>>[O:24]1[CH:28]=[CH:27][CH:26]=[C:25]1[C:29]([NH:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1)=[O:30]

Participants

3

Reactant 2

HCID 682422-Furancarbonyl chlorideHCID 117268345-Amino-3-(1-tert-butoxycarbonylpiperidin-4-yl)pyrrolo[3,2-b]pyridine

Product 1

HCID 196016425-(N-[2-furoyl]amino)-3-(piperidin-4-yl)pyrrolo[3,2-b]pyridine

Procedure

Beginning with 0.015 gm (0.047 mMol) 5-amino-3-(1-tert-butoxycarbonylpiperidin-4-yl)pyrrolo[3,2-b]pyridine and 0.006 mL (0.062 mMol) 2-furoyl chloride, the title compound was prepared.

Sources & evidence

ORD record
ord-5dc40eac733d4793a0073900f241a408
Source dataset
uspto-grants-1999_12
Patent number
US05998622

Linked notes

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