tert.-butyl (R)-(pyrrolidin-3-ylmethoxy)-acetate → HCID 178433195, compound
Reaction equation
[NH:1]([C:5]1[S:6][C:7]([C:11]([OH:13])=O)=[C:8]([CH3:10])[N:9]=1)[C:2]([NH2:4])=[NH:3].[NH:14]1[CH2:18][CH2:17][C@@H:16]([CH2:19][O:20][CH2:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:15]1>CO>[NH:1]([C:5]1[S:6][C:7]([C:11]([N:14]2[CH2:18][CH2:17][C@@H:16]([CH2:19][O:20][CH2:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:15]2)=[O:13])=[C:8]([CH3:10])[N:9]=1)[C:2]([NH2:4])=[NH:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
By coupling 2-guanidino-4-methyl-thiazole-5-carboxylic acid with tert.-butyl (R)-(pyrrolidin-3-ylmethoxy)-acetate according to the method given in Example 4 there is obtained tert.-butyl (R)-[1-(2-guanidino-4-methyl-thiazole-5-carbonyl)-pyrrolidin-3-ylmethoxy]-acetate as a pale yellow resinous foam, [α]D =+3.2°, (MeOH, c=0.5), MS: 398 (M+H)+.