Water → 2-Methoxy-6-(trifluoromethyl)benzoic acid

HRID 611720

Reaction equation

HRID 611720 reaction equation
[CH3:1][O-:2].[K+].F[C:5]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[C:6]=1[C:7]([OH:9])=[O:8].O>CO>[CH3:1][O:2][C:5]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[C:6]=1[C:7]([OH:9])=[O:8]

Participants

5

Reactant 3

HCID 962WaterHCID 6881232-Fluoro-6-(trifluoromethyl)benzoic acidHCID 23664618Potassium methoxide

Product 1

HCID 150175332-Methoxy-6-(trifluoromethyl)benzoic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of potassium methylate in methanol (15 ml, 15%) and 2-fluoro-6-trifluoromethylbenzoic acid (2.08 g, 0.01 mol) is heated to reflux with stirring for 40 hours. Upon cooling to room temperature water is added. The reaction mixture is filtered and the filtrate is acidified with concentrated hydrochloric acid. The solid material is collected by filtration, washed with water and dried yielding white crystals, 1.4 g (64%), mp 130-131° C.

Workup

  1. temperatureis heated
  2. temperatureto reflux
  3. additionis added
  4. filtrationThe reaction mixture is filtered
  5. filtrationThe solid material is collected by filtration
  6. washwashed with water
  7. customdried
  8. customyielding white crystals, 1.4 g (64%), mp 130-131° C.

Sources & evidence

ORD record
ord-59a931e776544b77ae6ea1b472ab51c4
Source dataset
uspto-grants-1999_12
Patent number
US06001883

Linked notes

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