2-Fluoro-5-(trifluoromethyl)pyridine → HCID 117727861, compound

HRID 61243

Reaction equation

HRID 61243 reaction equation
IC1C=CC=C(C)C=1C(O)=O.[NH2:12][CH2:13][C@@H:14]1[C@H:19]([CH3:20])[CH2:18][CH2:17][CH2:16][N:15]1[C:21]([C:23]1[C:28]([C:29]2[N:34]=[CH:33][CH:32]=[CH:31][N:30]=2)=[CH:27][CH:26]=[CH:25][C:24]=1[CH3:35])=[O:22].F[C:37]1[CH:42]=[CH:41][C:40]([C:43]([F:46])([F:45])[F:44])=[CH:39][N:38]=1>>[CH3:20][C@@H:19]1[CH2:18][CH2:17][CH2:16][N:15]([C:21]([C:23]2[C:28]([C:29]3[N:30]=[CH:31][CH:32]=[CH:33][N:34]=3)=[CH:27][CH:26]=[CH:25][C:24]=2[CH3:35])=[O:22])[C@@H:14]1[CH2:13][NH:12][C:37]1[CH:42]=[CH:41][C:40]([C:43]([F:46])([F:45])[F:44])=[CH:39][N:38]=1

Participants

4

Reactant 3

HCID 54637542-Fluoro-5-(trifluoromethyl)pyridineHCID 98565312-Iodo-6-methylbenzoic acidHCID 117728173HCID 117728173, compound

Product 1

HCID 117727861HCID 117727861, compound

Procedure

The title compound was prepared following the same general protocol as described for Example A230 using 2-iodo-6-methylbenzoic acid to make ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(2-methyl-6-(pyrimidin-2-yl)phenyl)methanone and 2-fluoro-5-(trifluoromethyl)pyridine. ESI-MS (m/z): 470 [M+1]+.

Sources & evidence

ORD record
ord-c2bed0fb38f7421fae54e6d1dbc6f1cd
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Linked notes

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