3-Aminosalicylic acid → (2-Bromophenyl)urea
Reaction equation
OC1C([NH2:11])=CC=CC=1C(O)=O.[Br:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N:19]=[C:20]=[O:21]>>[Br:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[NH:19][C:20](=[O:21])[NH2:11]Participants
3
Procedure
The urea was prepared from 2-hydroxy 3-amino benzoic acid (300 mg, 2 mmol) and 2-bromo phenyl isocyanate by general Method B. It was purified by dilution of the DMF solution with methylene chloride and precipitation with hexane (0.287 g. 41%). EI-MS m/z 351 (M+H)+
Workup
- customIt was purified by dilution of the DMF solution with methylene chloride and precipitation with hexane (0.287 g. 41%)
Sources & evidence
- ORD record
- ord-c16e054c3632477183b5d81845715f7a
- Source dataset
- uspto-grants-1999_12
- Patent number
- US06005008
Reaction notes
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