(S)-Benzyl 2-amino-3-methoxypropanoate hydrochloride → (S)-2-((S)-2-tert-butoxycarbonylamino-3-difluoromethoxy-propionylamino)-3-methoxy-propionic acid benzyl ester

HRID 61295

Reaction equation

HRID 61295 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH2:13][O:14][CH:15]([F:17])[F:16])[C:10]([OH:12])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[CH2:19]([O:26][C:27](=[O:33])[C@@H:28]([NH2:32])[CH2:29][O:30][CH3:31])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH2:19]([O:26][C:27](=[O:33])[C@@H:28]([NH:32][C:10](=[O:12])[C@@H:9]([NH:8][C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[CH2:13][O:14][CH:15]([F:17])[F:16])[CH2:29][O:30][CH3:31])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 69153484(S)-Benzyl 2-amino-3-methoxypropanoate hydrochlorideHCID 86709693(S)-2-tert-Butoxycarbonylamino-3-difluoromethoxy-propionic acid

Product 1

HCID 90040871(S)-2-((S)-2-tert-butoxycarbonylamino-3-difluoromethoxy-propionylamino)-3-methoxy-propionic acid benzyl ester

Procedure

The compound of Formula II(b)(ii) was prepared as an off-white foam in a similar manner as the compound of Formula II(a)(ii), described above, from the compound of Formula IV(a), (S)-2-tert-butoxycarbonylamino-3-difluoromethoxy-propionic acid and the compound of Formula V(b), (S)-2-amino-3-methoxy-propionic acid benzyl ester, hydrochloride salt.

Workup

  1. customThe compound of Formula II(b)(ii) was prepared as an off-white foam in a similar manner as the compound of Formula II(a)(ii)

Sources & evidence

ORD record
ord-8c426d448f92404ea77365e923e04078
Source dataset
uspto-grants-2016_09
Patent number
US09441012B2

Linked notes

Loading…