Ethanol → Ethyl 3-[4-(trifluoromethyl)phenyl]prop-2-enoate

Reaction equation

[F:1][C:2]([F:15])([F:14])[C:3]1[CH:13]=[CH:12][C:6]([CH:7]=[CH:8][C:9]([OH:11])=[O:10])=[CH:5][CH:4]=1.S(=O)(=O)(O)O.[CH2:21](O)[CH3:22]>>[F:1][C:2]([F:14])([F:15])[C:3]1[CH:4]=[CH:5][C:6]([CH:7]=[CH:8][C:9]([O:11][CH2:21][CH3:22])=[O:10])=[CH:12][CH:13]=1

Participants

Reactant 3

HCID 702Ethanol

HCID 1118Sulfuric Acid

HCID 749403-[4-(Trifluoromethyl)phenyl]prop-2-enoic acid

Product 1

HCID 53662772Ethyl 3-[4-(trifluoromethyl)phenyl]prop-2-enoateYield 95%

Procedure

4-Trifluoromethylcinnamic acid (10.2 g), conc. sulfuric acid (1 ml) and ethanol (100 ml) were subjected to reaction and post-treatment in a similar manner to that described in Reference example 10(a) to obtain the title compound (10.9 g, 95%) as a colorless oil.

Sources & evidence

ORD record: ord-647153e9d1d844f2812bd8057db26733
Source dataset: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06005116

Reaction notes

Loading…