HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 614Generated: October 24, 2026
8-Chloro-4-methyl-2-phenyl-3,4-dihydropyrido[3,2-F][1,4]oxazepin-5(2H)-one → 8-[3-Methoxy-4-(4-methylimidazol-1-yl)anilino]-4-methyl-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-5-one
https://huagongshe.com/en/reaction/614
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 8-Chloro-4-methyl-2-phenyl-3,4-dihydropyrido[3,2-F][1,4]oxazepin-5(2H)-one | HCID 59577825 | — |
| Reactant | 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline hydrochloride | HCID 67424235 | — |
| Reagent | Cesium carbonate | HCID 10796 | — |
| Catalyst | 2-(Dicyclohexylphosphino)biphenyl | HCID 2734216 | — |
| Catalyst | Palladium (II) acetate | HCID 4144353 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 8-[3-Methoxy-4-(4-methylimidazol-1-yl)anilino]-4-methyl-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-5-one | HCID 49820086 | 40.02% |
Reaction Steps
were placed in a microwave vial equipped with a stirring bar. The vial was capped and flushed with argon. DME (2 mL) and Et3N (0.028 mL, 0.20 mmol) were added via a syringe and the mixture was stirred at room temperature for 30 min and then heated to 100°C in a microwave apparatus for 1h. The reaction mixture was diluted with dichloromethane and ethyl acetate, fitered and concentrated. The residue was purified by reversed phase HPLC to give 37 mg of the product as a solid.
Provenance & Evidence
| Source dataset | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-322a5f0c927a43d5b08115d8443f975d |
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| Source note | 750 AstraZeneca ELN dataset |
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