HuagongsheHuagongshe Chemistry Print Report · For research reference only
Flutamide → N-[4-Amino-3-(trifluoromethyl)phenyl]-2-methylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Flutamide | HCID 3397 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-[4-Amino-3-(trifluoromethyl)phenyl]-2-methylpropanamide | HCID 16776651 | — |
Reaction Steps
Hydrogenate, at approximately 3 atmospheres, a mixture of 8.3 g. of 4'-nitro-3'-trifluoromethylisobutyranilide in 100 ml. of ethanol containing 0.5 g. of 5% palladium on charcoal. Filter and remove the solvent, obtaining 4'-amino-3'-trifluoromethylisobutyranilide, m.p. 114.5°-116° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04144270 |
| Source dataset | uspto-grants-1979_03 |
| ORD ID | ord-02a1de3a5d9142449202be4dd9fa9066 |
| Source note | uspto-grants-1979_03 |