Water → 2-Methyl-3-hydroxy-4-mercaptomethyl-5-vinylpyridine
Reaction equation
O.O.O.O.O.[S:6]([O-])([O-])(=O)=S.[Na+].[Na+].O.Cl.[CH3:15][C:16]1[C:21]([OH:22])=[C:20]([CH2:23]Cl)[C:19]([CH:25]=[CH2:26])=[CH:18][N:17]=1>C(O)C>[CH3:15][C:16]1[C:21]([OH:22])=[C:20]([CH2:23][SH:6])[C:19]([CH:25]=[CH2:26])=[CH:18][N:17]=1Participants
5
Conditions
- Temperature
- 75 °C
Procedure
A solution of 20 g. of sodium thiosulfate pentahydrate in 15 ml. of water is added to a solution of 18 g. of 2-methyl-3-hydroxy-4-chloromethyl-5-vinylpyridine hydrochloride in 100 ml. of 50% ethanol. The mixture is heated one hour at 75° C., cooled and evaporated to dryness to give Bunte salt of 2-methyl-3-hydroxy-4-mercaptomethyl-5-vinylpyridine, m.p. 198°-200° C.
Workup
- temperaturecooled
- customevaporated to dryness
Sources & evidence
- ORD record
- ord-5f18b1df2bc04322a520859ea822062d
- Source dataset
- uspto-grants-1979_03
- Patent number
- US04144342
Reaction notes
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