1-Pyrrolidineacetic acid, 2-methyl-5-oxo-, ethyl ester → cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-methyl-5-oxo-1-pyrrolidineacetamide

HRID 614473

Reaction equation

HRID 614473 reaction equation
[CH3:1][CH:2]1[CH2:6][CH2:5][C:4](=[O:7])[N:3]1[CH2:8][C:9]([O:11]CC)=O.[CH3:14][C@H:15]1[CH2:20][CH2:19][CH2:18][C@@H:17]([CH3:21])[N:16]1[CH2:22][CH2:23][NH2:24]>>[CH3:14][C@H:15]1[CH2:20][CH2:19][CH2:18][C@@H:17]([CH3:21])[N:16]1[CH2:22][CH2:23][NH:24][C:9](=[O:11])[CH2:8][N:3]1[C:4](=[O:7])[CH2:5][CH2:6][CH:2]1[CH3:1]

Participants

3

Reactant 2

HCID 5744761-Pyrrolidineacetic acid, 2-methyl-5-oxo-, ethyl esterHCID 7837022-(cis-2,6-Dimethyl-1-piperidinyl)ethanamine

Product 1

HCID 70610011cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-methyl-5-oxo-1-pyrrolidineacetamide

Procedure

From 9.26 g. of ethyl 2-methyl-5-oxo-1-pyrrolidineacetate (British Pat. No. 1,309,692) and 8.6 g. of cis-2-(2,6-dimethyl-1-piperidinyl)ethylamine, following the procedure of Example 9, there is obtained cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-methyl-5-oxo-1-pyrrolidineacetamide; m.p. 115°-116° C. after crystallization from cyclohexane.

Sources & evidence

ORD record
ord-88dc0e06b5634809b2f665ef092cad30
Source dataset
uspto-grants-1979_03
Patent number
US04145347

Linked notes

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