2-(cis-2,6-Dimethyl-1-piperidinyl)ethanamine → cis-(+/-)-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-alpha-methyl-2-oxo-1-pyrrolidineacetamide

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Reaction Steps

A mixture of 9.25 g. of ethyl α-methyl-2-oxo-1-pyrrolidineacetate (British Pat. No. 1,309,692) and 11.2 g. of cis-2-(2,6-dimethyl-1-piperidinyl)ethylamine is heated under nitrogen and an air condenser plugged with cotton for 20 hours at 150° C. The excess cis-2-(2,6-dimethyl-1-piperidinyl)ethylamine is evaporated at reduced pressure and the residue is fractionated. The product, cis-(±)-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-α-methyl-2-oxo-1-pyrrolidineacetamide, is obtained as an oil, b.p. 168°-170° C./0.1 mm.

Provenance & Evidence