HuagongsheHuagongshe Chemistry Print Report · For research reference only
Resorcinol → 2-Ethyl-4-(3-trifluoromethylphenyl)-7-hydroxy-2-methyl-2H-chromene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Resorcinol | HCID 5054 | — |
| Reactant | Boron trifluoride etherate | HCID 8000 | — |
| Reactant | Chromanone | HCID 68110 | — |
| Reactant | 2-Ethyl-7-hydroxy-2-methyl-4-chromanone | HCID 20570508 | — |
| Reactant | HCID 178506173 | HCID 178506173 | — |
| Product | 2-Ethyl-4-(3-trifluoromethylphenyl)-7-hydroxy-2-methyl-2H-chromene | HCID 20570565 | — |
Reaction Steps
2-Ethyl-7-hydroxy-2-methyl-4-chromanone, m.p. 109°-110.5° C., was prepared by condensing resorcinol with 3-methyl-2-pentanoic acid in the presence of boron trifluoride diethyl etherate. Reaction of the chromanone with 3-trifluoromethylphenyl magnesium bromide as described in Preparation 5 gave the title chromene as a golden yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04146539 |
| Source dataset | uspto-grants-1979_03 |
| ORD ID | ord-5bd9a4ba3af041a393e3f50f4cf9bc71 |
| Source note | uspto-grants-1979_03 |