4,4,6-Trimethyl-2,3,4,5-tetrahydropyrimidine → 4,4,6-Trimethyl-3,4,5,6-tetrahydropyrimidine

HRID 614895Notes

Reaction equation

HRID 614895 reaction equation
[CH3:1][C:2]1([CH3:9])[CH2:7][C:6]([CH3:8])=[N:5][CH2:4][NH:3]1>[Ni]>[CH3:1][C:2]1([CH3:9])[CH2:7][CH:6]([CH3:8])[N:5]=[CH:4][NH:3]1

Participants

3

Reactant 1

HCID 202254014,4,6-Trimethyl-2,3,4,5-tetrahydropyrimidine

Product 1

HCID 203301244,4,6-Trimethyl-3,4,5,6-tetrahydropyrimidine

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

A sample of 12 g. of 4,4,6-trimethyl-2,3,4,5-tetrahydropyrimidine and 1.0 g. of W-2 Raney nickel were heated under a hydrogen atmosphere at 178° C. for 18 hrs. to yield 4,4,6-trimethyl-3,4,5,6-tetrahydropyrimidine identical to the product described in example 1.

Sources & evidence

ORD record
ord-4eedb1352bac4a938339c7e7d33f40fe
Source dataset
uspto-grants-1979_03
Patent number
US04146714

Reaction notes

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