HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Norfloxacin hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Norfloxacin | HCID 4539 | — |
| Reactant | 1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid pentahydrate | HCID 70603524 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Norfloxacin hydrochloride | HCID 12733888 | — |
Reaction Steps
The compound (I) or (II) was dissolved in ethanol and acidified with concentrated hydrochloric acid. The resulting precipitate was collected, washed with ethanol, and dried to give 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride (III) as colorless needles, m.p. above 300° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04146719 |
| Source dataset | uspto-grants-1979_03 |
| ORD ID | ord-9db6c02d96a74a82888d23a4fe2324b2 |
| Source note | uspto-grants-1979_03 |