Hydrochloric Acid → Norfloxacin hydrochloride

HRID 614907

Reaction equation

HRID 614907 reaction equation
O.O.O.O.O.[CH2:6]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([F:24])=[C:15]([N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[CH:16]=2)[C:11](=[O:25])[C:10]([C:26]([OH:28])=[O:27])=[CH:9]1)[CH3:7].C(N1C2C(=CC(F)=C(N3CCNCC3)C=2)C(=O)C(C(O)=O)=C1)C.[ClH:52]>C(O)C>[ClH:52].[CH2:6]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([F:24])=[C:15]([N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[CH:16]=2)[C:11](=[O:25])[C:10]([C:26]([OH:28])=[O:27])=[CH:9]1)[CH3:7]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 4539NorfloxacinHCID 70603524HCID 70603524, compound

Product 1

HCID 12733888Norfloxacin hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The compound (I) or (II) was dissolved in ethanol and acidified with concentrated hydrochloric acid. The resulting precipitate was collected, washed with ethanol, and dried to give 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride (III) as colorless needles, m.p. above 300° C.

Workup

  1. customThe resulting precipitate was collected
  2. washwashed with ethanol
  3. customdried

Sources & evidence

ORD record
ord-9db6c02d96a74a82888d23a4fe2324b2
Source dataset
uspto-grants-1979_03
Patent number
US04146719

Linked notes

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