HuagongsheHuagongshe Chemistry Print Report · For research reference only
Norfloxacin → 1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid pentahydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Norfloxacin | HCID 4539 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid pentahydrate | HCID 70603524 | — |
Reaction Steps
The compound (II) was dissolved in 10% sodium hydroxide and neutralized with acetic acid. The precipitate was washed with water and dried at room temperature to afford 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrate (I) as colorless powder, m.p.: 226°-227° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04146719 |
| Source dataset | uspto-grants-1979_03 |
| ORD ID | ord-cd84b54551eb4287bbcf73cd49f6b746 |
| Source note | uspto-grants-1979_03 |