1-Diethoxyphosphorylethanamine → HCID 12673131, compound
Reaction equation
[NH2:1][CH:2]([P:4](=[O:11])([O:8][CH2:9][CH3:10])[O:5][CH2:6][CH3:7])[CH3:3].[CH:12](CC(OC(=O)CC=O)=O)=[O:13]>>[CH:12]([NH:1][CH:2]([P:4](=[O:11])([O:5][CH2:6][CH3:7])[O:8][CH2:9][CH3:10])[CH3:3])=[O:13]Participants
3
Conditions
- Temperature
- 120 °C
Procedure
A mixture of 3.6 g of diethyl α-aminoethyl-phosphonate prepared by the process of Chalmers et al, J.A.C.S., Vol 75 (1953), p. 5278 and 2 g of formylacetic acid anhydride stood overnight at room temperature and was then heated at 120° C. under a pressure of 0.5 to 1 mm Hg for 15 to 20 minutes. The residue was distilled to obtain pure diethyl 1-(N-formylamino)-ethyl-phosphonate with a boiling point of 148°~150° at 0.5 mm Hg which was used as is for the next step.
Workup
- customprepared by the process of Chalmers et al, J.A.C.S