Dimethylamine → Ethyl 2-dimethylaminomethylacrylate
Reaction equation
[CH2:1]=O.[C:3]([O:9][CH2:10][CH3:11])(=[O:8])[CH2:4][C:5]([O-])=O.[K+].[CH3:13][NH:14][CH3:15]>O>[CH3:13][N:14]([CH2:5][C:4](=[CH2:1])[C:3]([O:9][CH2:10][CH3:11])=[O:8])[CH3:15]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Formaldehyde (60 ml of 40% solution) was added to a stirred solution of potassium ethyl malonate (34g) and dimethylamine (40 ml of 26% solution) in water (100 ml) at 15° C. The solution was stirred at laboratory temperature for one hour and then boiled under reflux for one hour. After cooling the solution was extracted with ether and the ether was evaporated to leave the product as a yellow oil. This was distilled to give a clear oil (boiling point 84° C/20 mm).
Workup
- temperatureunder reflux for one hour
- temperatureAfter cooling the solution
- extractionwas extracted with ether
- customthe ether was evaporated
Sources & evidence
- ORD record
- ord-056f3d710dee46f49a7fd54ed0f847ad
- Source dataset
- uspto-grants-1978_02
- Patent number
- US04074051
Reaction notes
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