Phosgene → 10-fluoro-5H-dibenz[b,f]azepine-5-carbonyl chloride

HRID 616883

Reaction equation

[F:1][C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[NH:6][C:5]2[CH:13]=[CH:14][CH:15]=[CH:16][C:4]=2[CH:3]=1.[C:17](Cl)([Cl:19])=[O:18]>C1(C)C=CC=CC=1>[F:1][C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([C:17]([Cl:19])=[O:18])[C:5]2[CH:13]=[CH:14][CH:15]=[CH:16][C:4]=2[CH:3]=1

Participants

Conditions

Temperature: 25 °C

Procedure

A mixture of 2.3 g of 10-fluoro-5H-dibenz[b,f]azepine and 30 ml of toluene saturated with phosgene is stirred for 2 days at 25° C. Excess phosgene is then expelled with nitrogen and the reaction mixture is concentrated by rotary evaporation to yield crude 10-fluoro-5H-dibenz[b,f]azepine-5-carbonyl chloride as residue.

Workup

concentrationthe reaction mixture is concentrated by rotary evaporation

Sources & evidence

ORD record: ord-84342a3214e94d54b38ef2410a598ec3
Source dataset: uspto-grants-1978_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04076812

Linked notes

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