3-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-pyridine 1-oxide → 3-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-pyridine
Reaction equation
[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[CH2:7][O:8][C:9]1[CH:10]=[N+:11]([O-])[CH:12]=[C:13]([Br:15])[CH:14]=1.[H][H]>[Ni]>[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[CH2:7][O:8][C:9]1[CH:10]=[N:11][CH:12]=[C:13]([Br:15])[CH:14]=1Participants
4
Procedure
A sample of 3-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-5-bromo-pyridine-N-oxide, from Example 98a above, is reacted with hydrogen in the presence of Raney nickel according to the method of Y. Tamura et al., Heterocycles, 15:871-874 (1981). The solvents are removed, and the product is extracted, then purified by chromatography on silica gel.
Workup
- customThe solvents are removed
- extractionthe product is extracted
- custompurified by chromatography on silica gel
Sources & evidence
- ORD record
- ord-268f3882e74c4296929a25e089eff85f
- Source dataset
- uspto-grants-1999_09
- Patent number
- US05948793
Reaction notes
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