1,3-Benzodioxole-5-ethanamine → 4-[4-(3,4-Methylenedioxyphenethylamino)-6-trifluoromethyl-thieno-[2,3-d]-pyrimidin-2-yl]-benzoic acid methylester

HRID 617563Notes

Reaction equation

HRID 617563 reaction equation
[CH2:1]1[O:12][C:11]2[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH2:8])=[CH:4][C:3]=2[O:2]1.[CH3:13][O:14][C:15](=[O:36])[C:16]1[CH:21]=[CH:20][C:19]([C:22]2[N:23]=[C:24](Cl)[C:25]3[CH:30]=[C:29]([C:31]([F:34])([F:33])[F:32])[S:28][C:26]=3[N:27]=2)=[CH:18][CH:17]=1>>[CH3:13][O:14][C:15](=[O:36])[C:16]1[CH:21]=[CH:20][C:19]([C:22]2[N:23]=[C:24]([NH:8][CH2:7][CH2:6][C:5]3[CH:9]=[CH:10][C:11]4[O:12][CH2:1][O:2][C:3]=4[CH:4]=3)[C:25]3[CH:30]=[C:29]([C:31]([F:34])([F:33])[F:32])[S:28][C:26]=3[N:27]=2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 738741,3-Benzodioxole-5-ethanamineHCID 232894044-(4-Chloro-6-trifluoromethyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoic acid methylester

Product 1

HCID 232894634-[4-(3,4-Methylenedioxyphenethylamino)-6-trifluoromethyl-thieno-[2,3-d]-pyrimidin-2-yl]-benzoic acid methylester

Procedure

The reaction procedure as above wherein 3,4-methylenedioxyphenethylamine is reacted with 4-(4-chloro-6-trifluoromethyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoic acid methylester yields 4-[4-(3,4-methylenedioxyphenethylamino)-6-trifluoromethyl-thieno-[2,3-d]-pyrimidin-2-yl]-benzoic acid methylester.

Sources & evidence

ORD record
ord-7d9f28ef3ceb445a9fb89742436812b0
Source dataset
uspto-grants-1999_09
Patent number
US05948911

Reaction notes

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