2-Iodophenol → 4-(2-Iodophenoxymethyl)-1-methyl-1,2,3,6-tetrahydropyridine

Reaction equation

[OH:1][CH2:2][C:3]1[CH2:4][CH2:5][N:6]([CH3:9])[CH2:7][CH:8]=1.[I:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1O>>[I:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[O:1][CH2:2][C:3]1[CH2:8][CH2:7][N:6]([CH3:9])[CH2:5][CH:4]=1

Participants

Reactant 2

HCID 107842-Iodophenol

HCID 1189211,2,3,6-Tetrahydro-1-methylpyridine-4-methanol

Product 1

HCID 107350934-(2-Iodophenoxymethyl)-1-methyl-1,2,3,6-tetrahydropyridineYield 74%

Procedure

The title compound was prepared from 4-(hydroxymethyl)-1-methyl-1,2,3,6-tetrahydropyridine (D9) and 2-iodophenol, using a procedure similar to that of Description 1 in 74% yield.

Sources & evidence

ORD record: ord-99b56ac03cc64dc1ad0c748e9cfc6105
Source dataset: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05952325

Reaction notes

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