tert-Butyl isocyanate → 6-Arylpyrido[2,3-d]pyrimidine deriv. 41

HRID 617933

Reaction equation

HRID 617933 reaction equation
[NH2:1][C:2]1[C:3]([C:21]2[C:26]([Cl:27])=[CH:25][CH:24]=[CH:23][C:22]=2[Cl:28])=[CH:4][C:5]2[CH:10]=[N:9][C:8]([NH:11][CH2:12][C:13]([CH3:19])([CH3:18])[CH2:14][N:15]([CH3:17])[CH3:16])=[N:7][C:6]=2[N:20]=1.[C:29]([N:33]=[C:34]=[O:35])([CH3:32])([CH3:31])[CH3:30]>>[C:29]([NH:33][C:34]([NH:1][C:2]1[C:3]([C:21]2[C:26]([Cl:27])=[CH:25][CH:24]=[CH:23][C:22]=2[Cl:28])=[CH:4][C:5]2[CH:10]=[N:9][C:8]([NH:11][CH2:12][C:13]([CH3:19])([CH3:18])[CH2:14][N:15]([CH3:17])[CH3:16])=[N:7][C:6]=2[N:20]=1)=[O:35])([CH3:32])([CH3:31])[CH3:30]

Participants

3

Reactant 2

HCID 62412tert-Butyl isocyanateHCID 53281426-Arylpyrido[2,3-d]pyrimidine deriv. 40

Product 1

HCID 53281436-Arylpyrido[2,3-d]pyrimidine deriv. 41

Procedure

Following the procedure of Example 21, 1.0 g of 7-amino-6-(2,6-dichlorophenyl)-2-(3-dimethylamino-2,2-dimethyl-propylamino)-pyrido[2,3-d]pyrimidine from Example 29 was reacted with 0.26 g of t-butyl isocyanate to give the title compound; mp 161-170° C.

Sources & evidence

ORD record
ord-43a2cb155db741108cd7be823fcd8286
Source dataset
uspto-grants-1999_09
Patent number
US05952342

Linked notes

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