Phenylacetonitrile → 2,7-Diamino-6-phenylpyrido[2,3-d]pyrimidine

HRID 617965

Reaction equation

[C:1]1([CH2:7][C:8]#[N:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:10][C:11]1[N:16]=[C:15]([NH2:17])[C:14]([CH:18]=O)=[CH:13][N:12]=1>>[C:1]1([C:7]2[C:8]([NH2:9])=[N:17][C:15]3[N:16]=[C:11]([NH2:10])[N:12]=[CH:13][C:14]=3[CH:18]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 8794Phenylacetonitrile

HCID 3091762,4-Diaminopyrimidine-5-carbaldehyde

Product 1

HCID 108474752,7-Diamino-6-phenylpyrido[2,3-d]pyrimidine

Procedure

Following the procedure of Example 1, phenylacetonitrile was reacted with 2,4-diamino-5-pyrimidine-carboxaldehyde to give the title compound; mp 317-318° C.

Sources & evidence

ORD record: ord-197dc24ba39b490aa0ea07bd5004ba22
Source dataset: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05952342

Linked notes

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