4-Fluorothiophenol → HCID 21850267, compound

HRID 618081

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.Br[CH2:10][C:11]([C:13]1[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[C:15]([O:23][CH3:24])[CH:14]=1)=[O:12]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:10][C:11]([C:13]2[CH:14]=[C:15]([O:23][CH3:24])[C:16]([O:21][CH3:22])=[C:17]([O:19][CH3:20])[CH:18]=2)=[O:12])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 677894-Fluorothiophenol

HCID 36857322-Bromo-1-(3,4,5-trimethoxyphenyl)ethanone

Product 1

HCID 21850267HCID 21850267, compoundYield 125%

Procedure

Substantially the same procedure as in Reference Example 13 was repeated using 4-fluorothiophenol (0.82 g) and 2-bromo-3',4',5'-trimethoxyacetophenone (Compound XIa, 1.54 g) obtained in Reference Example 1 to give 2-(4-fluorophenylthio)-3',4',5'-trimethoxyacetophenone (Compound IX-11, 2.24 g).

Workup

customobtained in Reference Example 1

Sources & evidence

ORD record: ord-727724c945b9434a976ff1b0927fb6b0
Source dataset: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05952355

Linked notes

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