Nitric Acid → Acetamide, N-(2,4-dimethyl-5-nitrophenyl)-

HRID 618222

Reaction equation

HRID 618222 reaction equation
[N+:1]([O-:4])(O)=[O:2].[CH3:5][C:6]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:7]=1[NH:13][C:14](=[O:16])[CH3:15]>S(=O)(=O)(O)O>[CH3:5][C:6]1[CH:11]=[C:10]([CH3:12])[C:9]([N+:1]([O-:4])=[O:2])=[CH:8][C:7]=1[NH:13][C:14](=[O:16])[CH3:15]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 16303N-(2,4-Dimethylphenyl)acetamide

Product 1

HCID 112848Acetamide, N-(2,4-dimethyl-5-nitrophenyl)-

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Conditions

Temperature
0 °C

Procedure

A mixture of concentrated nitric acid (20 mL) and concentrated sulfuric acid (20 mL) was cooled in an ice-salt bath to 0° C. N-(2,4-dimethylphenyl)acetamide (9.5 g) was added portionwise at such a rate to maintain the temperature below 5° C. The mixture was then allowed to stir in the cold for an additional one hour.

Workup

  1. temperatureto maintain the temperature below 5° C

Sources & evidence

ORD record
ord-80511f65a2bb47f180d0bd088cb65e37
Source dataset
uspto-grants-1999_09
Patent number
US05952362

Linked notes

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