4-Fluorobenzyl bromide → 7-(1-Adamantyl)-6-(4-fluorobenzyl)oxy-2-bromonaphthalene

HRID 618488

Reaction equation

HRID 618488 reaction equation
[C:1]12([C:11]3[CH:20]=[C:19]4[C:14]([CH:15]=[CH:16][C:17]([Br:21])=[CH:18]4)=[CH:13][C:12]=3[OH:22])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[F:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28]Br)=[CH:26][CH:25]=1>>[C:1]12([C:11]3[CH:20]=[C:19]4[C:14]([CH:15]=[CH:16][C:17]([Br:21])=[CH:18]4)=[CH:13][C:12]=3[O:22][CH2:28][C:27]3[CH:30]=[CH:31][C:24]([F:23])=[CH:25][CH:26]=3)[CH2:8][CH:7]3[CH2:9][CH:3]([CH2:4][CH:5]([CH2:6]3)[CH2:10]1)[CH2:2]2

Participants

3

Reactant 2

HCID 680214-Fluorobenzyl bromideHCID 145490723-(Adamantan-1-yl)-6-bromonaphthalen-2-ol

Product 1

HCID 220003797-(1-Adamantyl)-6-(4-fluorobenzyl)oxy-2-bromonaphthaleneYield 86%

Procedure

Following the procedure of Example 1(a), but reacting 1.1 g (3 mmol) of 7-(1-adamantyl)-6-hydroxy-2-bromonaphthalene with 420 μl (3.3 mmol) of 4-fluorobenzyl bromide, 1.2 g (86%) of the expected compound were obtained in the form of a colorless oil.

Sources & evidence

ORD record
ord-5cd942cc1afd49239c01cac9b90b61ca
Source dataset
uspto-grants-1999_09
Patent number
US05952382

Linked notes

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