1,1-Dichloroacetone → 4,5-Difluoro-2-methoxybenzaldehyde

7.29 ml (66.3 mmol) of titanium tetrachloride were added while stirring to a solution, cooled to 0°, of 5.73 g (39.8 mmol) of 3,4-difluoroanisole in 30 ml of anhydrous dichloromethane. Subsequently, the mixture was treated dropwise over 10 minutes with 3.51 ml (39.6 mmol) of 1,1-dichloromethyl methyl ketone and stirred at room temperature for one hour. The mixture was poured into 100 ml of ice-water, extracted twice with 150 ml of dichloromethane each time and the combined organic phases were washed once with 100 ml of water and once with 100 ml of saturated sodium chloride solution. After drying over magnesium sulfate concentration was carried out in a vacuum. The crude product obtained was purified by column chromatography on silica gel (hexane/ethyl acetate 4:1). There were obtained 5.8 g (84%) of 4,5-difluoro-2-methoxybenzaldehyde as a white solid with m.p. 74°.

1. stirringstirred at room temperature for one hour
2. extractionextracted twice with 150 ml of dichloromethane each time
3. washthe combined organic phases were washed once with 100 ml of water and once with 100 ml of saturated sodium chloride solution
4. dry with materialAfter drying over magnesium sulfate concentration
5. customThe crude product obtained
6. customwas purified by column chromatography on silica gel (hexane/ethyl acetate 4:1)

ORD record

ord-5e33f5ae1f524c438b65b7409c6f1890

Source dataset

uspto-grants-1999_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05955495