2-Methyl-2-(4-vinylphenyl)propanoic acid → 2-(4-Ethylphenyl)-2-methylpropanoic acid
Reaction equation
[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]([CH3:14])([CH3:13])[C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1)=[CH2:2]>C(O)C.[C].[Pd]>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]([CH3:13])([CH3:14])[C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1)[CH3:2]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
2-(4-Vinylphenyl)-2-methylpropanoic acid (58 g) was dissolved in ethanol, and then stirred for 3 hrs under atmospheric hydrogen pressure in the presence of 10% palladium carbon (5.8 g). The catalyst was removed by filtration, and the filtrate was concentrated to obtain a crude product, which was then suspended and washed with hexane to give the title compound (56.5 g, 94.8%).
Workup
- customThe catalyst was removed by filtration
- concentrationthe filtrate was concentrated
- customto obtain a crude product, which
- washwashed with hexane
Sources & evidence
- ORD record
- ord-b5b10f936bab44d9be593fd78d91204d
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09440922B2
Reaction notes
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